MODE OF ACTION OF CHLORAMPHENICOL IV

Mode of Action of Chloramphenicol

Chloramphenicol has been shown to exert a strong inhibitory action on microbial protein synthesis (Gale and Folkes, 1953; Maxwell and Nickel, 1954; Wisseman et al., 1954). Hence, the hypotheses that the antibiotic may act simply as the antagonist of one amino acid or another are especially attractive (Mentzer et al., 1950; Woolley, 1950; Bergmann and Sicher, 1952; Molho and Molho-Lacroix, 1952)...

Mode of action of chloramphenicol. III. Action of chloramphenicol on bacterial energy metabolism.

evolution and mode of action of pulsed radiofrequency

Combined action of chloramphenicol and ampicillin on chloramphenicol-resistant Haemophilus influenzae.

The interaction of ampicillin and chloramphenicol on three ampicillin-susceptible, chloramphenicol-resistant strains of Haemophilus influenzae was studied by checkerboard testing with subcultures, time-kill experiments, and a disk method. In all three strains there was inhibition of the bactericidal action of ampicillin by chloramphenicol at concentrations close to the MIC (10 micrograms/ml). T...

Action of the N-trifluoroacetyl analogue of D-chloramphenicol.

The N-trifluoroacetyl analogue of chloramphenicol was found to inhibit the growth of Escherichia coli less than chloramphenicol, rather than more as previously reported by others. It also inhibits protein synthesis by E. coli and rat liver mitochondria less.